Yunjie Zhao
PhD Student
Telephone: +61 2 6268 8482
Fax: +61 2 6268 8017
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Field of Study: Biological Chemistry
Supervisor: Assoc. Prof. Grant Collins
Co-Supervisor: Dr Anthony Day
Research Topic - Cucurbit[n]uril- a delivery host for anti-cancer drugs
Multinuclear platinum complexes and the organic drug albendazole offer real potential for the treatment of cancer. However, and as with many other anti-cancer agents, their clinical use is limited by pharmacological problems. The potential of a relatively new class of macrocyclic host molecules, called cucurbit[n]uril (Q[n]), to act as a delivery system for these drugs and overcome the clinical drawbacks has been investigated. In order to examine particular aspects of the cucubit[n]uril binding of the drugs, new multinuclear platinum complexes and benzimidazole carbamate derivatives have been synthesized, and their biological activity compared to the parent compounds.